摘要 :
Hepatocellular carcinoma (HCC) is currently one of the most common tumors, with a high morbidity and mortality rate. HCC induced by persistent hepatitis B virus (HBV) infection is the most common liver cancer subtype at present, a...
展开
Hepatocellular carcinoma (HCC) is currently one of the most common tumors, with a high morbidity and mortality rate. HCC induced by persistent hepatitis B virus (HBV) infection is the most common liver cancer subtype at present, and HBV-related HCC is highly malignant and its development mechanism still needs to be explored in depth. This study aimed to explore the molecular mechanism of hsa_circ_0000847 targeting miR-135a-5p (miR-135a) to regulate the proliferation, invasion, and apoptosis of liver cancer cells. The study found that the expression level of hsa_circ_0000847 in liver cancer tissues and cells was significantly increased, while the expression level of miR-135a was significantly decreased. Hsa_circ_0000847 promoted the proliferation of liver cancer cells and elevated the expression of the proliferation-related protein. In addition, hsa_circ_0000847 could promote the invasion of HBV-infected liver cancer cells and inhibit the cell apoptosis of liver cancer cells. At the same time, it significantly promoted the expression of antiapoptotic proteins and inhibited the expression of proapoptotic protein. Interestingly, the dual luciferase experiment proved that hsa_circ_0000847 directly targeted miR-135a. On the other hand, the combined effect of hsa_circ_0000847 and miR-135a further illustrated the effect of hsa_circ_0000847 on the proliferation, invasion, and apoptosis of liver cancer cells. In addition, further experiments have also found that HBV could promote the expression of p-p38, p-ERK, and p-JNK through the hsa_circ_0000847/miR-135a axis, thereby further activating the MAPK pathway. In short, HBV promotes the proliferation and invasion of liver cancer cells and inhibits apoptosis by regulating the hsa_circ_0000847/miR-135a pathway, which provided a theoretical basis for effective treatment of HBV-infected liver cancers.
收起
摘要 :
Geotechnical applications based on soil resistivity measurement are becoming more popular in recent years. In order to explore the potential application of the electrical resistivity method in stabilization/solidification of conta...
展开
Geotechnical applications based on soil resistivity measurement are becoming more popular in recent years. In order to explore the potential application of the electrical resistivity method in stabilization/solidification of contaminated soils, two kinds of lead-contaminated soils stabilized with cement were prepared, and the electrical resistivity and unconfined compressive strength of specimens after curing for various periods were measured. The test results show that a high lead content leads to a low value of electrical resistivity of cement-stabilized soils, and increasing cement content and curing time result in a significant increase in electrical resistivity. The reduction in porosity and degree of saturation, as a result of the cement hydration process, leads to an increase in electrical resistivity. The ratio of porosity-lead content/cement content-curing time, combining together the effect of lead content, cement content, curing time, and porosity on electrical resistivity of stabilized soils, can be used as a fundamental parameter to assess electrical resistivity of cement-stabilized lead-contaminated soils. Archie's law can be extended to apply to cement-stabilized lead-contaminated soils by using this ratio, replacing the porosity. The new resistivity formula obtained in this paper is just empirical. There is a power function correlation between unconfined compressive strength and electrical resistivity of lead-contaminated soils stabilized with cement. Electrical resistivity measurement can be used as an economical and time-effective method to assess the quality of cement-stabilized lead-contaminated soils in practice.
收起
摘要 :
In this paper, we investigated a high gain dual-pump degenerate phase sensitive amplifiers. We achieved a 22-dB signal gain with a nonlinear phase shift of 2 rad in the 3-nm pump wavelength separation scheme. Here, we optimized th...
展开
In this paper, we investigated a high gain dual-pump degenerate phase sensitive amplifiers. We achieved a 22-dB signal gain with a nonlinear phase shift of 2 rad in the 3-nm pump wavelength separation scheme. Here, we optimized the fiber dispersion to weaken the de-amplification effect of high-order sidebands based on a 27-wave numerical model. By using such a narrow-wavelength-separation dual-pump phase sensitive amplifier scheme, we achieved a 3.3-dB optical signal-noise-ratio improvement compared with that of erbium doped fiber amplifier with the same gain. (C) 2017 Elsevier GmbH. All rights reserved.
收起
摘要 :
A novel radio-over-fiber (RoF) system with V-band and W-band millimeter-wave (MMW) signals is proposed. We begin our simulation by first utilizing a 20 GHz local oscillator (LO) to drive a dual-parallel Mach-Zehnder modulator (DP-...
展开
A novel radio-over-fiber (RoF) system with V-band and W-band millimeter-wave (MMW) signals is proposed. We begin our simulation by first utilizing a 20 GHz local oscillator (LO) to drive a dual-parallel Mach-Zehnder modulator (DP-MZM) and generate two quadruple frequency-interval coherent optical carriers. And then we use a dual-drive Mach-Zehnder modulator (DD-MZM) to load signal data and realize an optical single side-band (OSSB) modulation. Following these transmitted signals, we add a 50 km single-mode fiber (SMF) for signal transmission and aphotonics detector (PD) for signal self-heterodyning detection. Thanking to the mitigated chromatic dispersion (CD) effect of OSSB signals, the eye opening in the eye diagram is observed even after the transmission over 50 km of the SFM spool. The power penalties of the generated V-band 60 GHz and the W-band 100 GHz MMWs at a 10(-9) bit-error-rate (BER) are 1.7 dB and 2.5 dB, respectively. (C) 2016 Elsevier GmbH. All rights reserved.
收起
摘要 :
Ettringite is commonly used for the stabilization/solidification for heavy metal-contaminated soils, and its treatment effect will be influenced by Ca/Al mole ratio. Lead-contaminated soil samples were solidified using ettringite ...
展开
Ettringite is commonly used for the stabilization/solidification for heavy metal-contaminated soils, and its treatment effect will be influenced by Ca/Al mole ratio. Lead-contaminated soil samples were solidified using ettringite with different Ca/Al mole ratios. The pH value, unconfined compressive strength of solidified samples, and leaching concentration were investigated to understand the influence of Ca/Al mole ratio on properties of ettringite-solidified contaminated soils. The microstructural characteristics of solidified contaminated soils were also explored. The results show that lead leaching concentration decreases dramatically with increasing the content of lime and curing time. Lead concentration drops from 49.89mg/L to 0.19mg/L when Ca/Al mole ratio increases from 4:3 to 10:3 at 28 days and from 36.57mg/L to near 0mg/L at 90 days. In addition, the unconfined compressive strength of samples drops at first and then increases with the increase of Ca/Al mole ratio. Besides, the pH values of solidified soil and leachate rise with the increase of content of lime. The pH values of solidified soil increase from 9.68 to 11.34, and there is little difference between 28 days and 90 days. However, the pH values of leachate increase from 5.56 to 8.59 at 28 days, and 90-day pH values increase from 5.65 to 9.44. The results of SEM, XRD, and EDS tests also indicate that Ca/Al mole ratio affects the shape of ettringite, the stabilization/solidification effectiveness of contaminated soil, and the pore of solidified soil. When Ca/Al mole ratio equals to 8:3, ettringite content has a substantial increase, and lead leaching concentration is lower than 5mg/L.
收起
摘要 :
In this work, Cu nanoclusters (Cu NCs) with strong aggregation-induced electrochemiluminescence (AIECL) as emitters were used to construct an ECL biosensor for ultrasensitive detection of microRNA-141 (miR-141). Impressively, the ...
展开
In this work, Cu nanoclusters (Cu NCs) with strong aggregation-induced electrochemiluminescence (AIECL) as emitters were used to construct an ECL biosensor for ultrasensitive detection of microRNA-141 (miR-141). Impressively, the ECL signals enhanced with the increased content of Cu(I) in the aggregative Cu NCs. When the ratio of Cu(I)/Cu(0) in aggregative Cu NCs was 3.2, Cu NCs aggregates showed the highest ECL intensity, in which Cu(I) could enhance the cuprophilic Cu(I)center dot center dot center dot Cu(I) interaction to form rod-shaped aggregates for restricting nonradiative transitions to obviously improve the ECL response. As a result, the ECL intensity of the aggregative Cu NCs was 3.5 times higher than that of the monodispersed Cu NCs. With the aid of the cascade strand displacement amplification (SDA) strategy, an outstanding ECL biosensor was developed to achieve the ultrasensitive detection of miR-141, whose linear range varied from 10 aM to 1 nM with a detection limit of 1.2 aM. This approach opened an avenue to prepare non-noble metal nanomaterials as robust ECL emitters and provided a new idea for detection of biomolecules for diagnosis of disease.
收起
摘要 :
Purpose: To measure interleukin (IL)-17 serum levels in thoracic trauma patients and to correlate these levels with other cytokines and with patient prognosis.Methods: This prospective observational study recruited 130 thoracic tr...
展开
Purpose: To measure interleukin (IL)-17 serum levels in thoracic trauma patients and to correlate these levels with other cytokines and with patient prognosis.Methods: This prospective observational study recruited 130 thoracic trauma patients who were admitted to the Zhoupu Hospital Affiliated to Shanghai Medical College of Health June 2020 to April 2022 and 100 healthy volunteers. Patients were divided into two groups based on Injury Severity Score (ISS): ISS<16 (mild/moderate trauma) and ISS >= 16 (severe trauma). Serum IL-17, tumor necrosis factor alpha (TNF-alpha), IL-6, IL-1[3 and C-reactive protein (CRP) levels were measured by enzyme-linked immunosorbent assay. Patients with poor prognosis were defined as those who developed serious complications or died during hospitalization or follow-up.Results: Serum levels of IL-17, TNF-alpha, IL-6 and IL-1[3 were significantly elevated in patients with ISS >= 16 (p<0.05). Serum cytokines levels increased within 48 h in both groups and then gradually decreased during subse-quent treatment and rehabilitation. Pearson's analysis indicated a positive correlation among IL-17, TNF-alpha and IL-1[3. Serum IL-17 levels in patients with poor prognoses were higher than the patients with good prognoses at all time points (p<0.05). Furthermore, for patients with poor prognoses, the serum IL-17 levels had highest diagnostic value among all the cytokines measured. Logistic regression analysis showed that IL-17 was the risk factor for thoracic trauma patients with poor prognoses.Conclusion: Serum IL-17 levels were significantly elevated in thoracic trauma patients and decreased gradually with rehabilitation. IL-17 was a risk factor for thoracic trauma patients with poor prognoses. This study sug-gests a new diagnostic and therapeutic target for thoracic trauma patients.
收起
摘要 :
Al2O3-TiO2 (Al-Ti) composite oxide films are a promising dielectric material for future use in capacitors. In this study, TiO2 films were prepared on etched Al foils by vacuum infiltration. TiO2 films prepared using a sol-gel proc...
展开
Al2O3-TiO2 (Al-Ti) composite oxide films are a promising dielectric material for future use in capacitors. In this study, TiO2 films were prepared on etched Al foils by vacuum infiltration. TiO2 films prepared using a sol-gel process were annealed at various temperatures (450, 500, and 550 degrees C) for different time durations (10, 30, and 60 min) for 4 cycles, and then anodized at 100V. The specimens were characterized using X-ray diffraction, field emission scanning electron microscopy, and field emission transmission electron microscopy. The results show that the tunnels of the specimens feature a multi-layer structure consisting of an Al2O3 outer layer, an Al-Ti composite oxide middle layer, and an aluminum hydrate inner layer. The electrical properties of the specimens, such as the withstanding voltage and specific capacitance, were also measured. Compared to specimens without TiO2 coating, the specific capacitances of the TiO2-coated specimens are increased. The specific capacitance of the anode Al foil with TiO2 coating increased by 42% compared to that of a specimen without TiO2 coating when annealed at 550 degrees C for 10 min. These composite oxide films could enhance the specific capacitance of anode Al foils used in dielectric materials. (C) 2016 Elsevier B.V. All rights reserved.
收起
摘要 :
All-optical wavelength converters (AOWCs) based on state-of-the-art highly nonlinear optical fibers (HNLFs) are best matched with future large-capacity optical networks because of their characteristic of fast response. AOWCs play ...
展开
All-optical wavelength converters (AOWCs) based on state-of-the-art highly nonlinear optical fibers (HNLFs) are best matched with future large-capacity optical networks because of their characteristic of fast response. AOWCs play important roles in wavelength-routed optical networks to alleviate the constraint of conflicted wavelengths and in optical phase conjugation networks to mitigate the effects of fiber nonlinearities. Generally, conversion efficiency (CE) is a key evaluation index of AOWCs and higher CE corresponds to better transmission performance. However, it is challenging to achieve higher CE because the launched pump powers into HNLFs are usually limited by their stimulated Brillouin scattering thresholds. Actually, the performance of AOWCs, i.e., that of the idlers, depends on both of their CEs and the signal powers. Thus, it is feasible to achieve good performance for AOWCs with lower CEs as that with higher CEs by optimizing the launched signal powers into HNLFs. Our experimental results verified the above proposal in the AOWCs with the CEs of -23.1 dB, -19.1 dB, -15.2 dB, -11.4 dB and -7.9 dB. The proposed AOWCs was used as optical phase conjugation in the 64-QAM coherent optical transmission experimental system and good compensation performances have been achieved under the above five operating conditions.
收起
摘要 :
High-voltage etched aluminum foils were coated with BaTiO3 (BT) films by vacuum infiltration using a sol. The specimens coated with the BT films were annealed at 450-550 degrees C for 10-90 min, and this procedure was repeated sev...
展开
High-voltage etched aluminum foils were coated with BaTiO3 (BT) films by vacuum infiltration using a sol. The specimens coated with the BT films were annealed at 450-550 degrees C for 10-90 min, and this procedure was repeated several times (n = 0, 1, 2, 4, and 8 cycles), after which the specimens were finally anodized at 100-500 V. The BT films coated on the high-voltage etched aluminum foils were crystallized when annealed at 550 degrees C for 30 min. The thickness of the BT-coated layer decreased after the anodization, proving that the BT-coated layers were decomposed by the anodization, likely contributing to the formation of a BT-Al2O3 (BT-Al) composite oxide layer between the inner BT-coated layer and the outer Al2O3 layer. The maximum specific capacitance (C-S) of the specimens was obtained after 4 cycles of BT coating. The specific capacitances of the BT-coated specimens were higher than those of the specimens without the BT-film coating. The withstanding voltages of the specimens were approximately 123, 330, and 545 V when the specimens were anodized at 100, 300, and 500 V, respectively. These results suggest the successful fabrication of BT-Al composite oxide films on high-voltage etched aluminum foils. (C) 2016 Elsevier B.V. All rights reserved.
收起
原文获取